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Compound Tirzepatide Safety Information

At SpadeRx, we aim to provide transparent and comprehensive information about compounded tirzepatide to support informed decision-making. Below, you'll find details about its uses, risks, and important safety considerations.

What is Compound Tirzepatide?

Compound tirzepatide is a dual-action injectable medication that may help adults manage weight when paired with a reduced-calorie diet and increased physical activity. It works as both a GLP-1 and GIP receptor agonist, addressing weight-related conditions like hypertension, type 2 diabetes, or high cholesterol.

Who Should Use Compound Tirzepatide?

It is intended for:

  • Adults with a BMI of 30 or higher (obesity).
  • Adults with a BMI of 27 or higher (overweight) and at least one weight-related condition like diabetes or hypertension.

Who Should Avoid Compound Tirzepatide?

Do not use this medication if:

  • You or a family member have a history of medullary thyroid carcinoma (MTC).
  • You have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • You are pregnant, breastfeeding, or planning to become pregnant.

How is Compound Tirzepatide Taken?

  • Administer as a subcutaneous injection in the stomach, thigh, or upper arm once weekly.
  • Use the injection on the same day each week.
  • Follow your SpadeRX provider’s dosing recommendations carefully.

Important Safety Information

Thyroid Cancer Risk

In animal studies, tirzepatide caused thyroid tumors. The risk in humans is unknown. Notify your provider immediately if you notice symptoms like neck swelling, difficulty swallowing, or persistent hoarseness.

Serious Risks to Monitor

  • Pancreatitis: Seek medical attention for severe abdominal pain, with or without vomiting.
  • Gallbladder Issues: Watch for symptoms like stomach pain, jaundice, or pale stools.
  • Kidney Problems: Stay hydrated to avoid dehydration-related kidney issues.
  • Mental Health Changes: Report any mood changes or suicidal thoughts immediately.

Common Side Effects

  • Nausea, diarrhea, or vomiting
  • Constipation and indigestion
  • Fatigue or injection site reactions

Key Limitations

Compound tirzepatide is not FDA-approved, meaning it does not undergo the same rigorous safety and efficacy evaluations as FDA-approved medications. It should not be used with other GLP-1 receptor agonists or weight loss products.

Before Starting Compound Tirzepatide

Inform your provider about your medical history, including:

  • Thyroid conditions or cancer
  • Diabetes or diabetic retinopathy
  • Kidney or gastrointestinal diseases
  • Current medications, including supplements or over-the-counter products

If you are using oral contraceptives, switch to a non-oral method to maintain effectiveness or add a barrier method of contraception for 4 weeks after initiation and for 4 weeks after each dose escalation.

How to Use Safely

  • Read all instructions provided with the medication.
  • Rotate injection sites weekly to avoid irritation.
  • Never share injection pens to prevent infection risks.

Learn More

This summary provides essential information about compound tirzepatide but does not replace guidance from a SpadeRX provider. Always discuss your options with an SpadeRx professional to determine if compound tirzepatide is right for you.

SpadeRx provides access to compounded medications for qualified patients. Compounded medications are not FDA-approved and may differ in risks, benefits, and side effects compared to FDA-approved products. A licensed provider will perform a telehealth Good Faith Exam (GFE) to determine patient eligibility before any prescription is issued. Not all patients are candidates, and individual results may vary. Novo Nordisk Inc. and Eli Lilly and Company are the only U.S. manufacturers of FDA-approved semaglutide (Rybelsus®, Ozempic®, Wegovy®) and tirzepatide (Zepbound®, Mounjaro®), respectively. These manufacturers do not supply their medications for compounding.

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